Main K M, Price D A, Savage M O, Skakkebae N E
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.
J Clin Endocrinol Metab. 1993 Sep;77(3):821-3. doi: 10.1210/jcem.77.3.8370704.
Previous studies have shown that sweat secretion was reduced in patients with GH deficiency and increased during GH treatment, indicating an influence of GH on sweat gland function. Thus, patients with GH deficiency have impaired thermoregulation. We report on sweat secretion rates (SSRs) in seven patients with Laron syndrome, measured by pilocarpine iontophoresis. The patients had significantly lower SSRs than healthy children matched for sex and pubertal stage (P < 0.00005) and moderately, but significantly, elevated sweat electrolyte concentrations (P < 0.00005 for potassium; P < 0.01 for sodium). These observations further supported the hypothesis that sweat gland function in humans is under the influence of the GH-insulin-like growth factor-I axis. It remains to be seen whether the decrease in SSR also leads to altered thermoregulation in patients with Laron syndrome.
先前的研究表明，生长激素缺乏症患者的汗液分泌减少，而在生长激素治疗期间则增加，这表明生长激素对汗腺功能有影响。因此，生长激素缺乏症患者的体温调节功能受损。我们报告了7例拉伦综合征患者的汗液分泌率（SSR），通过毛果芸香碱离子导入法进行测量。这些患者的SSR显著低于年龄和青春期阶段相匹配的健康儿童（P < 0.00005），且汗液电解质浓度适度但显著升高（钾离子P < 0.00005；钠离子P < 0.01）。这些观察结果进一步支持了人类汗腺功能受生长激素-胰岛素样生长因子-I轴影响的假说。拉伦综合征患者的SSR降低是否也会导致体温调节改变仍有待观察。
