Main K, Nilsson K O, Skakkebaek N E
Department of Growth and Reproduction, Righospitalet, Copenhagen, Denmark.
Scand J Clin Lab Invest. 1991 Sep;51(5):475-80. doi: 10.3109/00365519109091642.
Sweat secretion rate (SSR) was measured by the pilocarpine iontophoresis test in (a) 254 healthy children and adolescents (aged 6.0 to 19.2 years, mean age 11.2 years); in (b) 58 healthy adults (aged 20.4 to 75.2 years, mean age 37.6 years); and in (c) eight prepubertal patients with growth hormone (GH) deficiency (aged 4.2 to 13.5 years, mean age 8.9 years). Boys had higher median values for SSR than girls (pre-pubertal children: 92.7 vs 64.5 mg 30 min-1 pubertal children: 110.3 vs 73.1 mg 30 min-1), and men showed higher values than women (135.5 vs 49.2 mg 30 min-1). In addition, the change in sweat excretion rate from childhood to adulthood showed a difference between the sexes. Both pre-pubertal and pubertal boys had a lower secretion value than adult men (p less than 0.001 and 0.01, respectively), whereas girls showed higher secretion values than adult women (p less than 0.01 and p less than 0.001, respectively). There was a significant increase in SSR from prepuberty to puberty (p less than 0.001) for both sexes. The children with GH deficiency, all pre-pubertal, showed significantly reduced SSR (p less than 0.001) compared with the healthy children (median values: 32.8 vs 80.0 mg 30 min-1). We conclude that (a) sweat secretion pattern in children shows a significant sex difference and (b) sweating in children is dependent on growth hormone.
通过毛果芸香碱离子导入试验测量了汗液分泌率（SSR）：(a) 254名健康儿童和青少年（年龄6.0至19.2岁，平均年龄11.2岁）；(b) 58名健康成年人（年龄20.4至75.2岁，平均年龄37.6岁）；以及(c) 8名青春期前生长激素（GH）缺乏症患者（年龄4.2至13.5岁，平均年龄8.9岁）。男孩的SSR中位数高于女孩（青春期前儿童：92.7 vs 64.5 mg 30分钟⁻¹；青春期儿童：110.3 vs 73.1 mg 30分钟⁻¹），男性的值高于女性（135.5 vs 49.2 mg 30分钟⁻¹）。此外，从儿童期到成年期汗液排泄率的变化存在性别差异。青春期前和青春期的男孩分泌值均低于成年男性（分别为p<0.001和p<0.01），而女孩的分泌值高于成年女性（分别为p<0.01和p<0.001）。两性从青春期前到青春期SSR均显著增加（p<0.001）。所有青春期前的GH缺乏症儿童与健康儿童相比，SSR显著降低（p<0.001）（中位数：32.8 vs 80.0 mg 30分钟⁻¹）。我们得出结论：(a) 儿童的汗液分泌模式存在显著的性别差异；(b) 儿童出汗取决于生长激素。
