Schluesener H J, Radermacher S, Melms A, Jung S
Institute of Brain Research, Neurological Clinic of Tübingen, Germany.
J Neuroimmunol. 1993 Sep;47(2):199-202. doi: 10.1016/0165-5728(93)90030-3.
Small antimicrobial peptides are abundantly produced by leukocytes. These peptides are active against a broad range of pathogens, notably bacteria, fungi and enveloped viruses, but hardly anything is known about their physiological and pathophysiological relevance. We observed that indolicidin, and to a lesser extent bactenecin, are strongly cytotoxic to rat and human T lymphocytes, while a variety of other cell lines are not affected by these endogenous antibiotics. The defensins HNP-1, HNP-2 and HNP-3, the structurally related but not bactericidal corticostatin, or cecropin P1 did not affect T lymphocyte viability or proliferation. Thus, indolicidin and bactenecin might function as local regulators inhibiting clonal expansion of T lymphocytes during ongoing immune responses. As immunosuppressive agents in the treatment of autoimmune disease, these peptides appear to be of limited potential, as systemic activity of such peptides is low, and we did not observe significant immunosuppressive effects in experimental autoimmune neuritis or encephalomyelitis.
小抗菌肽由白细胞大量产生。这些肽对多种病原体具有活性，特别是细菌、真菌和包膜病毒，但关于它们的生理和病理生理相关性却知之甚少。我们观察到，吲哚杀菌素以及程度稍轻的杆菌肽对大鼠和人类T淋巴细胞具有强烈的细胞毒性，而其他多种细胞系不受这些内源性抗生素的影响。防御素HNP-1、HNP-2和HNP-3、结构相关但无杀菌作用的促肾上腺皮质素，或天蚕素P1均不影响T淋巴细胞的活力或增殖。因此，吲哚杀菌素和杆菌肽可能作为局部调节剂，在正在进行的免疫反应中抑制T淋巴细胞的克隆扩增。作为治疗自身免疫性疾病的免疫抑制剂，这些肽的潜力似乎有限，因为此类肽的全身活性较低，而且我们在实验性自身免疫性神经炎或脑脊髓炎中未观察到明显的免疫抑制作用。
