Zhao C Y, Tam C C, Wong Y C
Department of Anatomy, Faculty of Medicine, University of Hong Kong, China.
J Morphol. 1993 Aug;217(2):219-27. doi: 10.1002/jmor.1052170209.
The morphogenesis of glandular architecture of the three lobes of prostate gland of the guinea pig, lateral, dorsal, and coagulating gland was studied from 35 days gestation to 90 postnatal days. Epithelial ductal tubules of various lobes of the gland were microdissected after treatment by collagenase and displayed two dimensionally. The number of ductal tips was counted, and the volume of the ductal network was quantified using a graphic tablet. The results show that the growth and ductal morphogenesis fall into two phases: prenatal and postnatal. The first outgrowth of prostatic buds begins at 35 days gestation (gestational length is 65 days). Ductal growth and branching continues over the next 15-20 days and by 55 days gestation, approximately 60%, 79%, and 71% of the adult number of ductal tips of the lateral and dorsal lobes and coagulating gland respectively, are formed. The figures increase to 89%, 84%, and 106%, respectively, by birth. There is little increase in number of ductal tips thereafter. Postnatal growth is accomplished mainly by elongation of existing ductal network with a little additional branching but with an increase in size (volume) of the tubules. Canalization of ductal tubules occurs prenatally in all lobes but postnatal functional cytodifferentiation takes a slightly different pace among them. Ductal morphogenesis of the guinea pig prostate gland differs significantly in time-course from that of the mouse in which ductal development occurs mainly postnatally.
对豚鼠前列腺三个叶（外侧叶、背侧叶和凝固腺）的腺性结构形态发生进行了研究，研究时段从妊娠35天至出生后90天。用胶原酶处理后，对腺体各叶的上皮导管小管进行显微解剖，并进行二维展示。统计导管末端数量，并用图形输入板对导管网络的体积进行量化。结果表明，生长和导管形态发生分为两个阶段：产前和产后。前列腺芽的首次长出始于妊娠35天（妊娠期为65天）。在接下来的15 - 20天内，导管生长和分支持续进行，到妊娠55天时，外侧叶、背侧叶和凝固腺的导管末端数量分别约为成年时的60%、79%和71%。到出生时，这些数字分别增至89%、84%和106%。此后，导管末端数量几乎不再增加。产后生长主要通过现有导管网络的延长来实现，伴有少量额外分支，但小管的大小（体积）会增加。导管小管的管道化在所有叶中均在产前发生，但产后功能细胞分化在各叶中的进展略有不同。豚鼠前列腺的导管形态发生在时间进程上与小鼠有显著差异，小鼠的导管发育主要在产后发生。
