Crespo P, Delgado M D, Gómez-Casares M T, Cuadrado M A, Richard C, León J
Departamento de Biología Molecular e Instituto de Estudios Avanzados de Biología Molecular del CSIC, Universidad de Cantabria, Santander, Spain.
Leuk Res. 1993 Sep;17(9):771-6. doi: 10.1016/0145-2126(93)90111-w.
Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-beta-D-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation.
载脂蛋白E（ApoE）是唯一在肝外组织中表达的载脂蛋白。研究了白血病K562细胞向红系或髓单核细胞系分化过程中的ApoE表达情况。当通过添加1-β-D-阿拉伯呋喃糖基胞嘧啶或羟基脲将K562细胞诱导分化为红系时，可检测到ApoE mRNA和蛋白水平升高。在佛波酯诱导的髓单核细胞分化过程中也观察到较弱的ApoE诱导现象。此前的研究已将ApoE表达与单核细胞分化联系起来。本文报道的研究结果表明，ApoE过表达与髓系分化中的特定谱系无关，且可能在红系分化中发挥作用。
