Weber J G, Ereth M H, Danielson D R
Department of Anesthesiology, Mayo Clinic Rochester, Minnesota 55905.
Mayo Clin Proc. 1993 Sep;68(9):842-5. doi: 10.1016/s0025-6196(12)60691-0.
The interruption of daily consumption of caffeine-containing beverages can cause headache and other symptoms within 8 hours. Resumption of caffeine alleviates these symptoms. Surgical patients routinely fast preoperatively and may have postoperative symptoms from caffeine withdrawal. In the current study, we determined whether perioperative caffeine consumption altered the incidence of postoperative headache. After institutional approval of the study design, 233 surgical outpatients were surveyed about history of headaches, caffeine consumption, and the presence and severity of headaches postoperatively. Of the 233 patients, 190 (82%) drank caffeinated beverages daily (mean daily consumption, 290 mg of caffeine). Postoperative headaches occurred in 22% of patients who routinely drank caffeinated beverages but in only 7% of those who did not (P < 0.03). Other factors associated with postoperative headaches included a history of frequent headaches (P < 0.0001), age of 50 years or younger (P < 0.002), and amount of daily caffeine ingested (P < 0.01). Among daily caffeine drinkers, those who drank caffeinated beverages on the day of the surgical procedure had a lower incidence of postoperative headaches than did those who abstained (17% versus 28%; P < 0.04). Postoperative headaches may be related to several factors. Perioperative intake of caffeine altered postoperative well-being. Caffeine given preoperatively may limit postoperative withdrawal headaches among the millions of daily drinkers of caffeinated beverages. A randomized, prospective, and blinded trial to test this hypothesis is warranted.
中断含咖啡因饮料的日常饮用可在8小时内引发头痛及其他症状。恢复饮用咖啡因可缓解这些症状。外科手术患者术前通常要禁食，可能会因咖啡因戒断出现术后症状。在本研究中，我们确定围手术期摄入咖啡因是否会改变术后头痛的发生率。在研究设计获得机构批准后，对233名外科门诊患者进行了关于头痛病史、咖啡因摄入情况以及术后头痛的存在和严重程度的调查。在这233名患者中，190名（82%）每天饮用含咖啡因饮料（平均每日咖啡因摄入量为290毫克）。常规饮用含咖啡因饮料的患者中22%出现术后头痛，而不饮用者中只有7%出现术后头痛（P<0.03）。与术后头痛相关的其他因素包括频繁头痛病史（P<0.0001）、年龄50岁及以下（P<0.002）以及每日咖啡因摄入量（P<0.01）。在每日饮用咖啡因的人群中，手术当天饮用含咖啡因饮料的患者术后头痛发生率低于未饮用者（17%对28%；P<0.04）。术后头痛可能与多种因素有关。围手术期摄入咖啡因会改变术后的健康状况。术前给予咖啡因可能会减少数百万每日饮用含咖啡因饮料者的术后戒断性头痛。有必要进行一项随机、前瞻性和盲法试验来验证这一假设。
