Schussheim A E, Radda G K
Department of Biochemistry, University of Oxford, United Kingdom.
Magn Reson Med. 1993 Jul;30(1):115-9. doi: 10.1002/mrm.1910300117.
We present a method for the direct correlation of quantitative changes in lactate concentration and intracellular pH during global ischemia in the perfused rat heart using rapidly interleaved 31P MRS and water-suppressed 1H MRS acquisitions. The ischemic myocardial buffering capacity was determined and found to be consistent with previous experimentation.