Nishimura K, Itoh H, Kitaichi M, Nagai S, Izumi T
Chest Disease Research Institute, Kyoto University, Japan.
Radiology. 1993 Oct;189(1):105-9. doi: 10.1148/radiology.189.1.8372178.
Computed tomographic (CT) findings of pulmonary sarcoidosis were correlated with histopathologic features determined at open lung biopsy or autopsy.
Eight patients (six men and two women, aged 22-65 years) with pulmonary sarcoidosis diagnosed at histologic examination were studied at CT with a high-spatial-frequency algorithm.
The most frequent CT features were irregularly thickened bronchovascular bundles (seven of eight cases [88%]) and small nodules along vessels (four cases [50%]). These features corresponded to granulomas formed in the connective tissue sheath around the pulmonary vessels and airways. This characteristic CT appearance was the result of the bronchovascular distribution of sarcoid granulomas. Granulomas adjacent to the visceral pleura or formed in the pleura in four patients were correlated with pleural or subpleural involvement. Ground-glass attenuation, present in six patients (75%), did not correlate with alveolitis in any patient.
CT is a valuable technique with which to visualize the characteristic location of sarcoid granulomas in the pulmonary parenchyma.
将肺结节病的计算机断层扫描（CT）表现与经开胸肺活检或尸检确定的组织病理学特征进行关联。
对8例经组织学检查确诊为肺结节病的患者（6名男性和2名女性，年龄22 - 65岁）进行了高空间频率算法的CT研究。
最常见的CT表现为支气管血管束不规则增厚（8例中的7例[88%]）和沿血管的小结节（4例[50%]）。这些表现对应于肺血管和气道周围结缔组织鞘内形成的肉芽肿。这种特征性的CT表现是结节病肉芽肿支气管血管分布的结果。4例患者中邻近脏层胸膜或在胸膜内形成的肉芽肿与胸膜或胸膜下受累相关。6例患者（75%）出现的磨玻璃样衰减与任何患者的肺泡炎均无关联。
CT是一种用于观察肺实质内结节病肉芽肿特征性位置的有价值技术。
