Wake A, Wada J A
Can J Neurol Sci. 1977 Feb;4(1):5-11.
Examination of the effects of primary site kindling upon the development of secondary site amygdaloid kindling in cats showed that the former exerts powerful positive as well as negative after effects upon the latter. The positive after effect appears to be directed towards establishing a linkage between the secondary site and the Stage 6 generalized convulsive mechanism. The negative after effects were strikingly similar to those observed in animals with forebrain bisection subjected to amygdaloid kindling, suggesting that it is primarily directed towards functional accessibility of the cerebral structures interconnected by the forebrain commissure. The similarity of the findings in animals with anterior neocortical lesions supports such an assumption. The transient nature of the negative after effects was indicated by the development of a 'normal' clinical ictal pattern from the secondary site when it occurred spontaneously. Secondary site kindling exerted similar but less prominent negative after effects when the primary site was re-tested. Stage 6 seizure was elicited upon the first trial, however.
对猫原发性位点点燃对继发性杏仁核点燃发展的影响进行检查后发现，前者对后者产生了强大的正向和负向后续效应。正向后续效应似乎旨在在继发性位点与6期全身性惊厥机制之间建立联系。负向后续效应与在接受杏仁核点燃的前脑切断动物中观察到的效应惊人地相似，这表明它主要针对由前脑连合相互连接的脑结构的功能可达性。前新皮层损伤动物的研究结果相似性支持了这一假设。负向后续效应的短暂性通过继发性位点自发出现时“正常”临床发作模式的发展得以体现。当对原发性位点进行重新测试时，继发性位点点燃产生了类似但不太明显的负向后续效应。然而，在第一次试验时就引发了6期癫痫发作。
