Tanaka M, Ishikawa T, Sakaguchi M
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Acta Pathol Jpn. 1993 Jul-Aug;43(7-8):360-6. doi: 10.1111/j.1440-1827.1993.tb01146.x.
An immunohistochemical study of HBV-associated antigen in the liver of 16 Japanese infants with biliary atresia revealed positive findings in 13 of the cases for HBc and/or HBs antigens. The positive cells were mainly small liver cells distributed in the peripheral zone of the lobule, and a few lymphocytes were observed in contact with or around the positive liver cells for HBV-associated antigen. Again, HBc antigen was demonstrated almost exclusively in the cytoplasm of positive liver cells. As these findings suggest the possibility of destruction and drop-out of cells constituting the interlobular bile duct in the junctional area by an immunological mechanism, the probability of HBV infection being an important factor in causing and accelerating biliary atresia cannot be denied. Positive findings for HBV-associated antigen similar to those found in biliary atresia are also seen in neonatal hepatitis and choledochal cysts. These conditions are therefore presumed to belong to the same category.
一项对16名患有胆道闭锁的日本婴儿肝脏中乙肝相关抗原的免疫组化研究显示，13例病例的乙肝核心抗原（HBc）和/或乙肝表面抗原（HBs）呈阳性。阳性细胞主要是分布在肝小叶周边区的小肝细胞，并且观察到一些淋巴细胞与乙肝相关抗原阳性肝细胞接触或在其周围。再者，几乎仅在阳性肝细胞的细胞质中证实有HBc抗原。由于这些发现提示存在通过免疫机制破坏和脱落构成汇管区小叶间胆管的细胞的可能性，因此不能否认乙肝病毒感染是导致和加速胆道闭锁的一个重要因素。在新生儿肝炎和胆总管囊肿中也可见到与胆道闭锁中相似的乙肝相关抗原阳性结果。因此，推测这些病症属于同一类别。
