Yamamura T, Hanai A, Oikawa H, Matsuzaki H, Kikuchi K, Akaishi O, Seo K, Ozasa T, Katayama K
First Dept. of Surgery, St. Marianna University School of Medicine.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1516-9.
Fifteen patients with liver metastases from colorectal cancer were treated by arterial infusion of 5-FU and leucovorin. Two regimens were performed. One was weekly bolus infusion of leucovorin following bolus infusion of 5-FU (bolus group), the other was 5 days continuous infusion of 5-FU and leucovorin in 3 weeks (continuous group). One PR was obtained both in the bolus group and in the continuous groups. The objective response rate was 11% in the bolus group and 20% in the continuous group. The one- and 2-year survival rates for these patients were 40% and 0% in the bolus group, and 80% and 60% in the continuous group, respectively. These results suggest that continuous arterial infusion of 5-FU and leucovorin was more effective than individual bolus arterial infusion of leucovorin and 5-FU for patients with liver metastases from colorectal cancer.
15例结直肠癌肝转移患者接受了5-氟尿嘧啶（5-FU）和亚叶酸钙的动脉灌注治疗。采用了两种治疗方案。一种是在5-FU推注后每周推注一次亚叶酸钙（推注组），另一种是在3周内连续5天输注5-FU和亚叶酸钙（连续输注组）。推注组和连续输注组均有1例患者获得部分缓解（PR）。推注组的客观缓解率为11%，连续输注组为20%。这些患者的1年和2年生存率在推注组分别为40%和0%，在连续输注组分别为80%和60%。这些结果表明，对于结直肠癌肝转移患者，持续动脉输注5-FU和亚叶酸钙比单独推注动脉输注亚叶酸钙和5-FU更有效。
