Seshimo A, Aratake T, Matsumoto M, Kawase A, Kirita T, Kameoka S, Hamano K
Dept. of Surgery II, Tokyo Women's Medical College.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2162-4.
Intraarterial infusion combination therapy with LV and 5-FU was performed on 8 patients with hepatic metastases from colorectal cancer. Briefly, immediately after administration of LV 30 mg/body, 5-FU was administrated in doses of 750 to 1,250 mg/body over about 2 hours. The therapy was repeated at every weekly visit to the clinic. The number of courses per patient averaged 22. The response rate was 50% (4 PR). Clinical responses were obtained 6 months on average. The 50% survival period was 300 days. Five patients died, 3 due to metastases to other sites. This therapy on an out-patient basis could be continued in all but one patient who was withdrawn from the treatment because of leucopenia. The results of this study suggest that this combination therapy is effective for hepatic metastasis from colorectal cancer.
对8例结直肠癌肝转移患者进行了亚叶酸钙（LV）和5-氟尿嘧啶（5-FU）的动脉内灌注联合治疗。简要地说，在给予每体质量30mg亚叶酸钙后，立即在约2小时内给予每体质量750至1250mg的5-氟尿嘧啶。每次到门诊就诊时重复该治疗。每位患者的疗程数平均为22个。有效率为50%（4例部分缓解）。平均6个月获得临床缓解。50%生存期为300天。5例患者死亡，3例死于其他部位转移。除1例因白细胞减少而退出治疗的患者外，所有患者均可在门诊继续进行该治疗。本研究结果表明，这种联合治疗对结直肠癌肝转移有效。
