Murotani M, Takami M, Fujimoto T, Takada T, Kitada M, Tsukahara Y, Okumura Y, Saito M, Shibata T, Watanabe Y
Dept. of Surgery, Toyonaka Municipal Hospital.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1650-3.
We investigated the usefulness of subselective intraarterial infusion chemotherapy in far advanced gastric and colorectal cancer. Among gastric and colorectal cancer cases undergoing surgery at our hospital for the past ten years, patients with and without palliative resection were studied. Forty gastric cancer patients and 29 colorectal cancer patients were treated by subselective intraarterial infusion chemotherapy. In gastric cancer cases without resection, a significantly longer survival was noted in patients undergoing this therapy with over 5 g of 5-FU than those treated with conventional chemotherapy. In gastric cancer patients with palliative resection and colorectal cancer patients, survival time was longer by intraarterial infusion with over 5 g of 5-FU, but not significant. Partial response was obtained in 5 cases of gastric cancer and 3 cases of colorectal cancer, and clinical symptoms were improved in 44% of the patients. The main complications of this therapy were myelosuppression and occlusion of the catheter, but none of them were serious. For the improved quality of life of cancer patients, subselective intraarterial infusion chemotherapy is considered a safe and useful form of treatment.
我们研究了亚选择性动脉内灌注化疗在晚期胃癌和结直肠癌中的应用价值。在我院过去十年接受手术治疗的胃癌和结直肠癌病例中，对接受姑息性切除和未接受姑息性切除的患者进行了研究。40例胃癌患者和29例结直肠癌患者接受了亚选择性动脉内灌注化疗。在未切除的胃癌病例中，接受5-氟尿嘧啶（5-FU）用量超过5g的该疗法患者的生存期明显长于接受传统化疗的患者。在接受姑息性切除的胃癌患者和结直肠癌患者中，5-FU用量超过5g的动脉内灌注化疗可延长生存时间，但差异不显著。5例胃癌患者和3例结直肠癌患者获得部分缓解，44%的患者临床症状得到改善。该疗法的主要并发症为骨髓抑制和导管阻塞，但均不严重。为提高癌症患者的生活质量，亚选择性动脉内灌注化疗被认为是一种安全有效的治疗方式。
