Fujita Y, Ota J, Fujita M, Sugimoto T, Sakamoto Y, Taguchi T
Dept. of Oncologic Surgery, Osaka University.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1653-6.
In advanced cancers the focus is frequently located widely in the intraabdominal organs below the diaphragm both in cases of postoperative recurrence and in unresectable cases. We have attempted subselective intraaortic injection therapy with carcinostatic agents for such cases. However, since the patients have advanced cancers, complete remission cannot be obtained and chances of rehabilitation are only for a definite period. Correct evaluation of the carcinostatic effect is difficult because the of complex nature of lesions. Hence, comparison by measurement of other than carcinostatic effect was attempted, and the period of survival was examined. Furthermore, it was believed useful in evaluating intraarterial infusion chemotherapy in cancer bearing patients to examine not only the survival for a long period but also the improvement in "quality of life" (QOL) based on factors other than direct effects, such as hospitalization period and at-home period.
在晚期癌症中，无论是术后复发还是无法切除的病例，病灶常常广泛位于膈肌以下的腹内器官。我们已尝试对这类病例采用向主动脉内进行亚选择性注射抗癌剂的治疗方法。然而，由于患者患有晚期癌症，无法实现完全缓解，康复机会也仅存在于一定时期内。由于病变性质复杂，难以对抗癌效果进行准确评估。因此，尝试通过测量抗癌效果以外的指标进行比较，并对生存时间进行了研究。此外，人们认为，在评估癌症患者的动脉内灌注化疗时，不仅要考察长期生存情况，还要基于住院时间和在家时间等直接影响以外的因素，考察“生活质量”（QOL）的改善情况，这对于评估动脉内灌注化疗是有益的。
