Lack E E, Cubilla A L, Woodruff J M, Farr H W
Cancer. 1977 Feb;39(2):397-409. doi: 10.1002/1097-0142(197702)39:2<397::aid-cncr2820390205>3.0.co;2-c.
Over a 38-year-period 73 paragangliomas from the head and neck region were seen at Memorial Hospital. These occurred in 69 patients. There were 44 carotid body, 13 vagal body, eight jugulo-tympanic, and three nasal paragangliomas. In addition, one each arose in the orbit, larynx, and area of the aortic arch. Sixty-two patients were surgically treated while three received irradiation only and four were observed but not treated. Follow-up was obtained for 94% of the patients. There were six postoperative deaths, five of which occurred before 1945. Of those treated surgically, 37 had no evidence of recurrent tumor while the paragangliomas recurred locally in 11. All patients in the radiation and untreated groups had persistent tumor. Malignant behavior with death due to tumor was observed in five cases (four carotid body and one vagal body paraganglioma). Using modern techniques carotid body and vagal body paragangliomas can usually be managed by surgery alone. Other paragangliomas of the head and neck due to their anatomic location are sometimes best treated by a combination of surgery and radiation or only by radiation therapy.
在38年的时间里，纪念医院共收治了73例头颈部副神经节瘤患者。这些患者共有69例。其中，44例为颈动脉体瘤，13例为迷走神经体瘤，8例为颈静脉鼓室副神经节瘤，3例为鼻腔副神经节瘤。此外，眼眶、喉部和主动脉弓区域各有1例发病。62例患者接受了手术治疗，3例仅接受了放疗，4例进行了观察但未接受治疗。94%的患者获得了随访。术后死亡6例，其中5例发生在1945年之前。在接受手术治疗的患者中，37例无肿瘤复发迹象，11例肿瘤局部复发。放疗组和未治疗组的所有患者肿瘤均持续存在。5例出现肿瘤相关死亡的恶性行为（4例颈动脉体瘤和1例迷走神经体瘤）。采用现代技术，颈动脉体瘤和迷走神经体瘤通常仅通过手术即可治疗。头颈部的其他副神经节瘤由于其解剖位置的原因，有时最好采用手术与放疗相结合的方法治疗，或仅采用放疗。
