Benness G, Khangure M, Morris I, Warwick A, Burrows P
Nuclear Medicine Department, QEII Medical Centre, Nedlands, Western Australia.
Australas Radiol. 1993 Aug;37(3):252-5. doi: 10.1111/j.1440-1673.1993.tb00067.x.
This complex study was designed to measure the transport and excretion characteristics of gadolinium ethoxybenzyl diethylenetriaminepentacetic acid (Gd-EOB-DTPA) in dog's livers following bolus and infusion. Simultaneous T1 magnetic resonance imaging was performed to measure maximum signal enhancement. Anaesthetized dogs had cannulation of the common bile duct and urinary bladder for collections and cannulation of the femoral artery and vein for monitoring, blood sampling and infusion. Gd-EOB-DTPA was administered by bolus (range 12.5-200 mumol/kg) and infusion (range 0.4-6.4 mumol/min per kg). An hepatic transport maximum 0.09-0.15 mumol/min/kg was achieved with a blood concentration of 0.03-0.06 mumol/mL. Marked hepatic affinity for Gd-EOB-DTPA was demonstrated with measurements of liver concentration. Maximum T1 signal enhancement was achieved with blood Gd-EOB-DTPA concentration of 0.02-0.03 mumol/mL and a liver concentration of 1-2 mumol/g. The transport maximum for Gd-EOB-DTPA in the dog was similar to that for ipodate and iodipamide and effective imaging was achieved with sub-maximal doses. The maximum signal enhancement at blood concentrations less than required for maximum transport suggest a wide latitude for effective clinical imaging.
这项复杂的研究旨在测量大剂量注射和输注钆塞酸二钠（Gd-EOB-DTPA）后在犬肝脏中的转运和排泄特征。同时进行T1磁共振成像以测量最大信号增强。对麻醉后的犬进行胆总管和膀胱插管以进行收集，并对股动脉和静脉进行插管以进行监测、采血和输注。Gd-EOB-DTPA通过大剂量注射（范围为12.5 - 200 μmol/kg）和输注（范围为0.4 - 6.4 μmol/min per kg）给药。当血药浓度为0.03 - 0.06 μmol/mL时，肝脏转运最大值为0.09 - 0.15 μmol/min/kg。通过测量肝脏浓度证明了Gd-EOB-DTPA对肝脏有明显的亲和力。当血药浓度为0.02 - 0.03 μmol/mL且肝脏浓度为1 - 2 μmol/g时，可实现最大T1信号增强。犬体内Gd-EOB-DTPA的转运最大值与碘番酸和碘他拉酸相似，并且使用次最大剂量即可实现有效成像。血药浓度低于最大转运所需浓度时的最大信号增强表明有效临床成像有很大的灵活性。
