阿司匹林对实验性抗磷脂综合征复发性流产的影响。

The effect of aspirin on recurrent fetal loss in experimental antiphospholipid syndrome.

作者信息

Krause I, Blank M, Gilbrut B, Shoenfeld Y

机构信息

Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Am J Reprod Immunol. 1993 Apr;29(3):155-61. doi: 10.1111/j.1600-0897.1993.tb00581.x.

DOI:10.1111/j.1600-0897.1993.tb00581.x

PMID:8373524

Abstract

PURPOSE

To evaluate the effect of aspirin treatment upon fetal loss in mice with experimental antiphospholipid syndrome (APLS).

MATERIALS AND METHODS

Experimental APLS was induced in pregnant mice by passive transfer of mouse monoclonal anticardiolipin antibody. The mice were treated with high (100 micrograms/d) or low (10 micrograms/d) dose of aspirin, using vitamin C (100 micrograms/d or 10 micrograms/d) as a control. The mice were assessed for the presence of lupus anticoagulants (prolonged aPTT), thrombocytopenia, degree of fetal resorption rate and mean embryo and placental weights.

RESULTS

The mice with APLS had a higher fetal resorption rate (45.7 +/- 12.2% vs 2.5 +/- 0.4%, P < 0.001), reduced placenta mean weight (104 +/- 8 mg vs 169 +/- 7 mg, P < 0.001), prolonged aPTT (94 +/- 14 sec vs 39 +/- 4 sec, P < 0.001), and reduced mean platelet count (597 +/- 186 x 10(3)/mm3 vs 847 +/- 51 x 10(3)/mm3, P < 0.001). The group of mice with APLS, who were treated with low-dose aspirin, had a lower resorption rate (11.1 +/- 9.3% vs 45.7 +/- 12.2%, P < 0.001), a higher placenta mean weight (178 +/- 8 mg vs 104 +/- 8 mg, P < 0.001), a higher mean embryo weight (1042 +/- 134 mg vs 721 +/- 91 mg, P < 0.001), and a lower aPTT (58 +/- 15 sec vs 94 +/- 14 sec, P < 0.001). Mice who were treated with high-dose aspirin also had a lower resorption rate, although not as much as in the low-dose aspirin group (34.2 +/- 12.7% vs 45.7 +/- 12.2%, P < 0.001).

CONCLUSION

Aspirin, especially in low dose, has a protective effect against obstetrical complications associated with experimental APLS.

摘要

目的

评估阿司匹林治疗对实验性抗磷脂综合征（APLS）小鼠胎儿丢失的影响。

材料与方法

通过被动转移小鼠单克隆抗心磷脂抗体诱导孕鼠发生实验性APLS。将小鼠分为高剂量（100微克/天）或低剂量（10微克/天）阿司匹林治疗组，以维生素C（100微克/天或10微克/天）作为对照。评估小鼠狼疮抗凝物（活化部分凝血活酶时间延长）、血小板减少症、胎儿吸收率以及平均胚胎和胎盘重量。

结果

APLS小鼠的胎儿吸收率更高（45.7±12.2%对2.5±0.4%，P<0.001），胎盘平均重量降低（104±8毫克对169±7毫克，P<0.001），活化部分凝血活酶时间延长（94±14秒对39±4秒，P<0.001），平均血小板计数降低（597±186×10³/立方毫米对847±51×10³/立方毫米，P<0.001）。低剂量阿司匹林治疗的APLS小鼠组吸收率较低（11.1±9.3%对45.7±12.2%，P<0.001），胎盘平均重量较高（178±8毫克对104±8毫克，P<0.001），平均胚胎重量较高（1042±134毫克对721±91毫克，P<0.001），活化部分凝血活酶时间较短（58±15秒对94±14秒，P<0.001）。高剂量阿司匹林治疗的小鼠吸收率也较低，尽管不如低剂量阿司匹林组明显（34.2±12.7%对45.7±12.2%，P<0.001）。