Hussain M, Wozniak A J, Edelstein M B
Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
Crit Rev Oncol Hematol. 1993 Feb;14(1):61-75. doi: 10.1016/1040-8428(93)90006-p.
to review the neurotoxicity associated with antineoplastic agents.
four hundred articles, abstracts and book chapters were selected for review. One hundred and ninety (articles, book chapters and abstracts) were identified as representative of the important aspects of neurotoxicity to be presented in this review.
in general the dose, schedule and route of administration significantly determine the incidence and outcome of antineoplastic agents neurotoxicity. An updated and detailed review of neurotoxicity is provided with special attention to vinca alkaloids, cisplatin and biologic response modifiers. The neurotoxic side effects of some of the new approaches in cancer therapy and some of the investigational agents are discussed. Guidelines for the prevention and management of this toxicity are presented. In addition, suggestions are made in regard to the preclinical and clinical screening of new agents for neurotoxicity.
quality of life issues have become a focal point in many clinical trials. Neurotoxicity associated with antineoplastic therapy clearly has an impact on the short and long term quality of the life of cancer patients. A better understanding of this toxicity requires developing reliable and predictive models to screen new agents prior to their introduction into clinical trials; a more detailed and uniform grading system; and the prospective evaluation of neurotoxicity in clinical trials of new antineoplastic agents.
综述与抗肿瘤药物相关的神经毒性。
选取400篇文章、摘要和书籍章节进行综述。其中190篇（文章、书籍章节和摘要）被确定为本次综述中神经毒性重要方面的代表。
总体而言，剂量、给药方案和给药途径显著决定了抗肿瘤药物神经毒性的发生率和结果。本文对神经毒性进行了更新且详细的综述，特别关注长春花生物碱、顺铂和生物反应调节剂。讨论了癌症治疗中一些新方法及某些研究性药物的神经毒性副作用。提出了预防和管理这种毒性的指南。此外，还就新药神经毒性的临床前和临床筛查提出了建议。
生活质量问题已成为许多临床试验的焦点。与抗肿瘤治疗相关的神经毒性显然会对癌症患者的短期和长期生活质量产生影响。要更好地理解这种毒性，需要开发可靠且具有预测性的模型，以便在新药进入临床试验前对其进行筛查；需要更详细和统一的分级系统；以及在新抗肿瘤药物的临床试验中对神经毒性进行前瞻性评估。
