Dyke M P, Grauaug A, Kohan R, Ott K, Andrews R
Department of Newborn Services, King Edward Memorial Hospital for Women, Subiaco, Western Australia.
J Paediatr Child Health. 1993 Aug;29(4):295-7. doi: 10.1111/j.1440-1754.1993.tb00515.x.
The incidence of Ureaplasma colonization at birth and its effect on the development of chronic lung disease (CLD) and on mortality was studied in a neonatal intensive care population. Ureaplasma colonization was associated with a birthweight < 1000 g (odds ratio [OR] 3.45 confidence intervals [CI] 2.13-5.60) and a gestational age < 30 weeks (OR 2.54 CI 1.71-3.79). In a case-controlled study of 112 infants, significant associations with Ureaplasma colonization were maternal pyrexia in labour (n = 38 vs 21; P = 0.015), the requirement for antibiotics in labour (n = 39 vs 16; P = 0.0005) and vaginal delivery (n = 78 vs 58; P = 0.009). Risk factors associated with the development of CLD were birthweight < 1000 g (OR 3.77 CI 2.53-5.62) and delivery by Caesarean section (OR 1.65 CI 1.11-2.43). Within the group delivered by Caesarean section. Ureaplasma colonization was also associated with an increased risk of CLD (OR 1.97 CI 1.08-3.62). Ureaplasma colonization of infants at birth is associated with factors suggestive of maternal chorioamnionitis as well as preterm birth and low birthweight. In infants delivered by Caesarean section, Ureaplasma colonization is associated with an increased risk of chronic lung disease.
在新生儿重症监护人群中，研究了出生时解脲脲原体定植的发生率及其对慢性肺病（CLD）发展和死亡率的影响。解脲脲原体定植与出生体重<1000g（优势比[OR]3.45，置信区间[CI]2.13 - 5.60）和胎龄<30周（OR 2.54，CI 1.71 - 3.79）相关。在一项对112名婴儿的病例对照研究中，与解脲脲原体定植有显著关联的因素包括产时母体发热（n = 38 vs 21；P = 0.015）、产时使用抗生素的需求（n = 39 vs 16；P = 0.0005）和阴道分娩（n = 78 vs 58；P = 0.009）。与CLD发展相关的危险因素是出生体重<1000g（OR 3.77，CI 2.53 - 5.62）和剖宫产分娩（OR 1.65，CI 1.11 - 2.43）。在剖宫产分娩的人群中，解脲脲原体定植也与CLD风险增加相关（OR 1.97，CI 1.08 - 3.62）。婴儿出生时解脲脲原体定植与提示母体绒毛膜羊膜炎的因素以及早产和低出生体重有关。在剖宫产分娩的婴儿中，解脲脲原体定植与慢性肺病风险增加有关。
