Iles R, Lyon A, Ross P, McIntosh N
Neonatal Unit, Simpson Memorial Maternity pavilion, Edinburgh, UK.
Acta Paediatr. 1996 Apr;85(4):482-4. doi: 10.1111/j.1651-2227.1996.tb14067.x.
In a prospective cohort study in a tertiary referral neonatal intensive care unit, the endotracheal secretions of 40 consecutively intubated newborn infants, less than 31 weeks' gestation, were examined weekly for the genital mycoplasmas and all other common bacterial pathogens. Fifteen (37%) infants were positive for Ureaplasma urealyticum and/or Mycoplasma hominis. There were no differences in gestation, birthweight, use of surfactant, or time on ventilator between the culture-positive and negative babies. Thirteen (87%) of the culture-positive group developed chronic lung disease (CLD) compared with 11 (41%) of the negative group (p = 0.0196). Of those culture-positive, 37% were not identified on the first specimen taken at the time of admission. These data suggest a significant association between infection with the urogenital mycoplasma and CLD and also stress the need for repeated cultures to identify these organisms.
在一家三级转诊新生儿重症监护病房进行的一项前瞻性队列研究中，对40例孕周小于31周且连续接受气管插管的新生儿每周进行气管内分泌物检查，以检测生殖支原体及所有其他常见细菌病原体。15例（37%）婴儿解脲脲原体和/或人型支原体呈阳性。培养阳性和阴性婴儿在孕周、出生体重、表面活性剂使用情况或机械通气时间方面无差异。培养阳性组中有13例（87%）发生慢性肺部疾病（CLD），而阴性组为11例（41%）（p = 0.0196）。在那些培养阳性的婴儿中，37%在入院时采集的第一份标本中未被检测出。这些数据表明泌尿生殖支原体感染与CLD之间存在显著关联，同时也强调了需要重复培养以识别这些病原体。
