Irgens L M, Oyen N, Skjaerven R
Medical Birth Registry of Norway, Bergen.
Acta Paediatr Suppl. 1993 Jun;82 Suppl 389:23-5. doi: 10.1111/j.1651-2227.1993.tb12869.x.
Whether or not genetic factors play a role in sudden infant death syndrome represents an important question with respect to both etiology and prevention, and to counselling. An increased recurrence risk would define a high-risk group, essential from a preventive point of view. From an etiological perspective, an increased recurrence risk might indicate either genetic and/or highly stable environmental factors. On the other hand, an identical or only slightly increased recurrence risk would represent strong evidence that genetic factors are not involved in SIDS and would question future search for genetic markers. The acquisition of large materials (a recurrence risk in the population of 6-7 per 1,000,000) necessary to adequately elucidate the issue, represents important methodological problems which have hampered the interpretation of the results to date. Estimates of the risk increase (rate ratios) range from 10 to no significant increase. Data from population-based recurrence studies suggest only a minor, if any, increase, but further elucidation of the issue is needed.
基因因素是否在婴儿猝死综合征中起作用，这在病因学、预防以及咨询方面都是一个重要问题。复发风险的增加将界定出一个高危群体，从预防角度来看这至关重要。从病因学角度而言，复发风险的增加可能表明存在遗传和/或高度稳定的环境因素。另一方面，相同或仅略有增加的复发风险将有力证明基因因素与婴儿猝死综合征无关，并对未来寻找基因标记提出质疑。获取足够阐明该问题所需的大量样本（人群中复发风险为每100万中有6 - 7例）存在重要的方法学问题，这些问题迄今阻碍了对结果的解读。风险增加的估计值（率比）范围从10到无显著增加。基于人群的复发研究数据表明，即便有增加，也只是轻微增加，但仍需要进一步阐明该问题。
