Schultz W J, Brownfield M S, Kozlowski G P
Cell Tissue Res. 1977 Mar 1;178(1):129-41. doi: 10.1007/BF00232830.
Light and electron microsopic examination of choroid plexuses from lateral ventricles of water-deprived and subcutaneously or intravenously vasopressin administered rats reveal morphologic changes typical for vasopressin responsive fluid transporting epithelia during hormonal stimulation. Ultrastructural changes noted in both dehydrated and vasopressin treated animals included: the frequent occurrence of choroidal "dark" cells, dilatation of the lateral and basal intercellular spaces, increased vacuolization of the apical cytoplasm, and a change in microvillar conformation from the normal clavate type to those with a filiforma shape. On the basis of the ultrastructural changes observed it is proposed that the choroids plexus be regarded as a target tissue for vasopressin. These findings indicated that a vasopressin mediated transchoroidal cerebrospinal fluid absorption capability exists.
对缺水以及皮下或静脉注射血管加压素的大鼠侧脑室脉络丛进行光镜和电镜检查发现，在激素刺激期间，血管加压素反应性液体运输上皮细胞出现典型的形态学变化。在脱水和血管加压素处理的动物中均观察到的超微结构变化包括：脉络膜“暗”细胞频繁出现、细胞外侧和基底间隙扩张、顶端细胞质空泡化增加以及微绒毛形态从正常的棒状变为丝状。基于观察到的超微结构变化，有人提出脉络丛应被视为血管加压素的靶组织。这些发现表明存在血管加压素介导的经脉络丛脑脊液吸收能力。
