van den Bos C, Kieboom D, Wagemaker G
Department of Radiobiology, Erasmus University, Rotterdam, The Netherlands.
Bone Marrow Transplant. 1993 Jul;12(1):9-13.
beta-Thalassemic mice were transplanted with normal congeneic BM cells after sublethal total body irradiation, which resulted in partial RBC chimerism and correction of anemia. Enumeration of donor-type early hemopoietic progenitor cells (CFU-S) demonstrated that the correction of anemia originated from a minority of normal immature BM cells. It is concluded that successful BMT in beta-thalassemia does not necessarily require ablation of endogenous BM.
