Obladen M, Maier R F
Department of Neonatology, Children's Hospital, UniversiTätsklinikum Rudolf Virchow, Berlin, Germany.
Curr Opin Pediatr. 1993 Apr;5(2):156-61. doi: 10.1097/00008480-199304000-00004.
Respiratory disorders remain a major cause of neonatal mortality and morbidity. This review focuses on clinical trials and diagnostic procedures in neonatal respiratory disorders reported from October 1991 to September 1992. It leaves out animal studies, artificial ventilation techniques, extracorporeal membrane oxygenation, and follow-up studies. Surfactant substitution comes of age and first side effects of this successful treatment are described. Infection with ureaplasma urealyticum seems to contribute to chronic lung disease. The latter can be effectively treated with dexamethasone. However, because of numerous and severe side effects, this treatment requires scrupulous risk-benefit evaluation in each case.
呼吸系统疾病仍然是新生儿死亡和发病的主要原因。本综述聚焦于1991年10月至1992年9月间报道的新生儿呼吸系统疾病的临床试验和诊断程序。它未包括动物研究、人工通气技术、体外膜肺氧合及随访研究。表面活性剂替代疗法已成熟，并描述了这种成功治疗的首批副作用。解脲脲原体感染似乎与慢性肺病有关。后者可用地塞米松有效治疗。然而，由于有众多严重副作用，这种治疗在每种情况下都需要严格的风险效益评估。
