肺表面活性物质疗法
Pulmonary surfactant therapy.
作者信息
Poulain F R, Clements J A
机构信息
Department of Pediatrics, University of California, San Francisco, School of Medicine.
出版信息
West J Med. 1995 Jan;162(1):43-50.
Abstract
Surfactant replacement therapy is now an integral part of the care of neonates since several clinical trials of natural surfactant extracts and synthetic preparations have shown efficacy in the treatment of infants with hyaline membrane disease. In these studies, early treatment with exogenous surfactant substantially reduced mortality and the incidence of air leak, although it did not appear to reduce the incidence of other complications, in particular bronchopulmonary dysplasia. Early reports of exogenous surfactant therapy in patients with the adult respiratory distress syndrome, although promising, remain limited in number. More research is needed to improve on current modes of therapy and to investigate the possible role of surfactant in other lung diseases of both newborns and adults.
摘要
由于多项天然表面活性剂提取物和合成制剂的临床试验已表明其在治疗透明膜病婴儿方面的疗效，表面活性剂替代疗法现已成为新生儿护理的一个组成部分。在这些研究中，外源性表面活性剂的早期治疗显著降低了死亡率和气漏发生率，尽管它似乎并未降低其他并发症的发生率，尤其是支气管肺发育不良的发生率。关于外源性表面活性剂疗法在成人呼吸窘迫综合征患者中的早期报道虽然很有前景，但数量仍然有限。需要更多的研究来改进当前的治疗模式，并研究表面活性剂在新生儿和成人其他肺部疾病中的可能作用。
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