Low L C
Department of Paediatrics, University of Hong Kong, Queen Mary Hospital, Pokfulam.
J Pediatr Endocrinol. 1993 Jan-Mar;6(1):15-20. doi: 10.1515/jpem.1993.6.1.15.
As a significant number of children with growth hormone deficiency have been shown to be able to respond to GHRH with a rise in serum growth hormone (GH) levels, GHRH has been used to treat such children with varying success. GHRH has been given subcutaneously (SC) in GH deficient children to improve growth in dose frequencies of daily, twice daily, three-hourly overnight or three-hourly throughout the day. The dosages of GHRH used have been wide ranging, varying from 4 micrograms/kg/day to 50 micrograms/kg/day. Continuous infusion of GHRH has been shown to augment GH secretion in normal adults and GH deficient children without evidence of desensitization of the somatotrophs. Continuous SC infusion of GHRH has been shown to promote growth in short slowly growing children. Poor growth response to GHRH has been reported by some authors using daily SC injection while others reported significant growth acceleration in 42-87% of GH deficient children treated using different GHRH regimens. Although GH treatment in GH-deficient children results in more consistent growth acceleration, comparable growth response can be seen in some children treated with GHRH. The optimal mode of GHRH therapy remains to be determined, but it would appear that the growth response is dependent on the dose used and possibly on the frequency of administration.(ABSTRACT TRUNCATED AT 250 WORDS)
由于大量生长激素缺乏的儿童已被证明能够对生长激素释放激素（GHRH）产生反应，血清生长激素（GH）水平会升高，因此GHRH已被用于治疗此类儿童，取得了不同程度的成功。在生长激素缺乏的儿童中，已采用皮下注射（SC）GHRH，以在每日、每日两次、夜间每三小时或全天每三小时的给药频率下促进生长。所使用的GHRH剂量范围很广，从4微克/千克/天到50微克/千克/天不等。在正常成年人和生长激素缺乏的儿童中，持续输注GHRH已被证明可增加生长激素分泌，且没有生长激素细胞脱敏的证据。持续皮下输注GHRH已被证明可促进身材矮小、生长缓慢儿童的生长。一些作者报告，每日皮下注射GHRH时生长反应不佳，而另一些作者则报告，在采用不同GHRH治疗方案的生长激素缺乏儿童中，42%至87%有显著的生长加速。尽管对生长激素缺乏的儿童进行生长激素治疗能更持续地促进生长加速，但在一些接受GHRH治疗的儿童中也能看到类似的生长反应。GHRH治疗的最佳方式仍有待确定，但生长反应似乎取决于所用剂量，可能还取决于给药频率。（摘要截选至250词）
