Deletion of chromosome 13 in osteosarcoma secondary to irradiation.
作者信息
Ozisik Y Y, Meloni A M, Zalupski M M, Ryan J R, Qureshi F, Sandberg A A
机构信息
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
出版信息
Cancer Genet Cytogenet. 1993 Aug;69(1):35-7. doi: 10.1016/0165-4608(93)90109-y.
PMID:8374897
Abstract
The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.
摘要
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