Mascarello J T, Krous H F, Carpenter P M
Genetic Services, Children's Hospital and Health Center, San Diego, CA 92123.
Cancer Genet Cytogenet. 1993 Aug;69(1):65-7. doi: 10.1016/0165-4608(93)90116-4.
We report results of the first cytogenetic study of an osteoblastoma. Cells from the tumor were characterized by a three-way unbalanced translocation involving chromosomes 15, 17, and 20. As a consequence of the translocation, most of one chromosome 17 short arm appears to have been lost. This loss suggests the possibility that loss of 17p DNA sequences may be involved in early changes leading to neoplastic proliferation of osteoblasts.
我们报告了首例骨母细胞瘤的细胞遗传学研究结果。肿瘤细胞的特征是涉及15号、17号和20号染色体的三向不平衡易位。由于这种易位，17号染色体短臂的大部分似乎已经丢失。这种丢失提示17p DNA序列的丢失可能参与了导致成骨细胞肿瘤性增殖的早期变化。
