Thornhill A R, Burgoyne P S
MRC Mammalian Development Unit, London, UK.
Development. 1993 May;118(1):171-4. doi: 10.1242/dev.118.1.171.
It has previously been shown that XO mouse fetuses with a paternally derived X chromosome (Xp) are developmentally retarded and consequently smaller than their XX sibs, and that XX fetuses are retarded when compared with their XY sibs. The genetic basis for these early XO-XX and XX-XY differences has not been determined. Here we show that 10.5 day post coitum XO mouse fetuses with a maternal X chromosome, rather than being smaller than their XX sibs, are significantly larger and equivalent in size to their XY sibs. Thus the retardation of XpO fetuses must be due to an effect of their paternally derived X chromosome. The finding that XmO fetuses are larger than XX fetuses and equivalent in size to XY fetuses suggests that the XX-XY difference present at 10.5 days post coitum is largely due to the difference in X chromosome constitution rather than to a Y chromosome effect.
此前已有研究表明，具有父源X染色体（Xp）的XO小鼠胎儿发育迟缓，因此比其XX同胞更小，并且与XY同胞相比，XX胎儿也发育迟缓。这些早期XO-XX和XX-XY差异的遗传基础尚未确定。在此我们表明，交配后10.5天具有母源X染色体的XO小鼠胎儿，并非比其XX同胞更小，而是明显更大，且与XY同胞大小相当。因此，XpO胎儿的发育迟缓必定归因于其父源X染色体的影响。XmO胎儿比XX胎儿更大且与XY胎儿大小相当这一发现表明，交配后10.5天出现的XX-XY差异很大程度上是由于X染色体组成的差异，而非Y染色体的影响。
