Yoshikawa T
First Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Eur Neurol. 1993;33 Suppl 1:60-8. doi: 10.1159/000118539.
In recent years, it has been shown that active oxygen species or free radicals are closely involved in various diseases. Accumulating information supports the hypothesis that oxidative stress involving lipid peroxidation may contribute to the pathogenesis of Parkinson's disease. The objectives of this review are, first, to discuss some of the roles of active oxygen species in the pathogenesis of Parkinson's disease; second, to examine the possible effects of antioxidants as the protective therapy for Parkinson's disease, and, third, to summarize results from in vitro experiments that the dopamine agonist bromocriptine, used for treatment of Parkinson's disease, has a strong antioxidative effect.
近年来，研究表明活性氧或自由基与多种疾病密切相关。越来越多的信息支持这样一种假说，即涉及脂质过氧化的氧化应激可能在帕金森病的发病机制中起作用。本综述的目的，首先是讨论活性氧在帕金森病发病机制中的一些作用；其次，研究抗氧化剂作为帕金森病保护性治疗的可能效果；第三，总结体外实验结果，即用于治疗帕金森病的多巴胺激动剂溴隐亭具有很强的抗氧化作用。
