Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Evid Based Complement Alternat Med. 2012;2012:823206. doi: 10.1155/2012/823206. Epub 2011 Jul 18.
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200-250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.
氧化应激被报道会导致帕金森病患者的认知障碍。本文旨在确定具有抗氧化活性的物质槲皮素对帕金森病大鼠模型认知功能的影响。雄性 Wistar 大鼠，体重 200-250g，在右侧黑质单侧损毁诱导前 14 天和损毁后 14 天每天口服给予槲皮素，剂量为 100、200、300mg/kgBW。在治疗的第 7 天和第 14 天评估其空间记忆，在实验结束时测定神经元密度、丙二醛（MDA）水平、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性。此外，还测定了乙酰胆碱酯酶（AChE）的活性。结果发现，槲皮素的所有剂量都增强了空间记忆。因此，建议槲皮素的认知增强作用部分是由于氧化损伤减少导致神经元密度增加所致。
