Debus-Thiede G, Maassen V, Dimpfl T, Klosterhalfen T, Kindermann G
I. Frauenklinik der Universität München.
Geburtshilfe Frauenheilkd. 1993 Aug;53(8):525-31. doi: 10.1055/s-2007-1022927.
Permanent disturbances of bladder function are the most unpleasant and least tolerated side effects in patients, who underwent Wertheim hysterectomy because of cervical cancer. The cause of this problem with respect to the radical nature of the operation in relation to the possibly and responsible anatomical structures (sacrouterine ligament, parametrium, paracolpium) has not been completely elucidated. The aim of this prospective study was, to determine this interrelation in 39 (out of 120 radically hysterectomised) patients subjected to urodynamic examination preoperatively and 6-8 months postoperatively after Wertheim hysterectomy. With regard to preserved or lost postoperative bladder sensitivity, no correlation was found to either the length of the vaginal cuff or the parametric tissue. A statistically significant correlation was found between the length of the resected parametric tissue and the onset of postoperative stress urinary incontinence. Furthermore, there was a statistically significant correlation between the length of the resected vaginal cuff and the bladder capacity. The urodynamic parameters of maximum flow-rate, flow-time and residuals correlated rather with the radical nature of removal of the parametrial tissue than with the radicality of the vaginal resection, but that was not significant. The study leads to the conclusion, that within the variations of radical hysterectomy with medium radicality (Wagner-Wertheim procedure), the results presented here are not strikingly different regarding postoperative disturbances of bladder function. To determine such differences, investigations after more radical procedures (e.g. Latzko) would be more suitable.
对于因宫颈癌接受韦特海姆子宫切除术的患者而言,膀胱功能的永久性紊乱是最令人不适且最难耐受的副作用。就手术的根治性与可能相关且起作用的解剖结构(骶子宫韧带、子宫旁组织、阴道旁组织)而言,这一问题的成因尚未完全阐明。这项前瞻性研究的目的是,在39名(120名接受根治性子宫切除术患者中的)患者中确定这种相互关系,这些患者在术前以及韦特海姆子宫切除术后6 - 8个月接受了尿动力学检查。关于术后膀胱敏感性的保留或丧失,未发现与阴道袖口长度或子宫旁组织存在相关性。在切除的子宫旁组织长度与术后压力性尿失禁的发生之间发现了具有统计学意义的相关性。此外,切除的阴道袖口长度与膀胱容量之间存在统计学意义的相关性。最大流速、排尿时间和残余尿量的尿动力学参数与子宫旁组织切除的根治程度相关性更大,而非与阴道切除术的根治程度相关,但这并不显著。该研究得出结论,在中等根治程度的根治性子宫切除术(瓦格纳 - 韦特海姆手术)的变化范围内,此处呈现的结果在膀胱功能术后紊乱方面并无显著差异。要确定此类差异,对更根治性手术(如拉茨科手术)后的研究将更为合适。