Kemp B, Kitschke H J, Goetz M, Heyl W
Department of Obstetrics and Gynecology, Technical University Hospital, Aachen, Germany.
Int Urogynecol J Pelvic Floor Dysfunct. 1997;8(3):138-41. doi: 10.1007/BF02764845.
The efficacy of betanecholchloride in the postoperative treatment of bladder dysfunction is controversial. We therefore performed a comparative study on the effect of this therapy for the prophylaxis of detrusor hypotonia after Wertheim-Meigs operation. Forty patients with cervical cancer FIGO stage Ib/IIa were divided into two study groups. The control group (24 patients) only received betanecholchloride if the residual urine persisted above 50 ml after the 10th postoperative day. The study group (16 patients) received 50 mg betanecholchloride three times a day from the 3rd postoperative day onward. In this group postoperative catheter treatment, and consequently hospital stay, were significantly shorter (9.6 versus 13.3 days and 15.5 versus 18.6 days). The residual urinary volume normalized faster (8.0 versus 13.0 days) and the rate of cystitis was lower (18.8 versus 25%). According to our study, a prophylactic application of the parasympathomimetic drug betanecholchloride diminishes postoperative complications associated with bladder dysfunction after Wertheim-Meigs operation.
氯化氨甲酰甲胆碱在膀胱功能障碍术后治疗中的疗效存在争议。因此，我们对该疗法预防韦特海姆-梅格斯手术后逼尿肌张力减退的效果进行了一项对比研究。40例国际妇产科联盟（FIGO）分期为Ib/IIa期的宫颈癌患者被分为两个研究组。对照组（24例患者）仅在术后第10天残余尿量持续超过50 ml时才接受氯化氨甲酰甲胆碱治疗。研究组（16例患者）从术后第3天起每天接受3次50 mg氯化氨甲酰甲胆碱治疗。该组术后导尿治疗时间及住院时间显著缩短（分别为9.6天对13.3天以及15.5天对18.6天）。残余尿量恢复正常的速度更快（8.0天对13.0天），膀胱炎发生率更低（18.8%对25%）。根据我们的研究，预防性应用拟副交感神经药物氯化氨甲酰甲胆碱可减少韦特海姆-梅格斯手术后与膀胱功能障碍相关的术后并发症。
