Sica G, Iacopino F, Lama G, Marchetti P, Carenza L, Dell'Acqua S, De Cicco Nardone F, Lombardi A, Mariani L, Villani C
Instituto di Istologia ed Embriologia, Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.
Gynecol Oncol. 1993 Aug;50(2):185-90. doi: 10.1006/gyno.1993.1190.
Forty-three patients with primary endometrial carcinoma were treated with natural interferon-beta (IFN-beta) at two different dose levels (2 x 10(6) IU or 6 x 10(6) IU im 3 times/week for 1 week). IFN-beta increased receptors for estrogens (ER) and progesterone (PR) in a high percentage of the 40 evaluable patients, without modifying the receptor affinity. The ER and PR enhancement, which was simultaneous in at least 50% of patients, and the increase of over 100 fmol/mg protein observed in some cases suggest that IFN-beta exerts a profound influence on receptor expression and, probably, on the hormone sensitivity of the tumor.
43例原发性子宫内膜癌患者接受了两种不同剂量水平的天然β-干扰素（IFN-β）治疗（2×10⁶IU或6×10⁶IU，肌肉注射，每周3次，共1周）。在40例可评估患者中，IFN-β使高比例患者的雌激素受体（ER）和孕激素受体（PR）增加，而受体亲和力未改变。至少50%的患者ER和PR同时增强，部分病例中观察到蛋白增加超过100 fmol/mg，这表明IFN-β对受体表达以及可能对肿瘤的激素敏感性有深远影响。
