原发性子宫内膜癌中的天然β干扰素治疗与甾体激素受体

Natural interferon-beta treatment and steroid hormone receptors in primary endometrial cancer.

作者信息

Sica G, Iacopino F, Lama G, Marchetti P, Carenza L, Dell'Acqua S, De Cicco Nardone F, Lombardi A, Mariani L, Villani C

机构信息

Instituto di Istologia ed Embriologia, Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Gynecol Oncol. 1993 Aug;50(2):185-90. doi: 10.1006/gyno.1993.1190.

DOI:10.1006/gyno.1993.1190

PMID:8375733

Abstract

Forty-three patients with primary endometrial carcinoma were treated with natural interferon-beta (IFN-beta) at two different dose levels (2 x 10(6) IU or 6 x 10(6) IU im 3 times/week for 1 week). IFN-beta increased receptors for estrogens (ER) and progesterone (PR) in a high percentage of the 40 evaluable patients, without modifying the receptor affinity. The ER and PR enhancement, which was simultaneous in at least 50% of patients, and the increase of over 100 fmol/mg protein observed in some cases suggest that IFN-beta exerts a profound influence on receptor expression and, probably, on the hormone sensitivity of the tumor.

摘要

43例原发性子宫内膜癌患者接受了两种不同剂量水平的天然β-干扰素（IFN-β）治疗（2×10⁶IU或6×10⁶IU，肌肉注射，每周3次，共1周）。在40例可评估患者中，IFN-β使高比例患者的雌激素受体（ER）和孕激素受体（PR）增加，而受体亲和力未改变。至少50%的患者ER和PR同时增强，部分病例中观察到蛋白增加超过100 fmol/mg，这表明IFN-β对受体表达以及可能对肿瘤的激素敏感性有深远影响。