Testoni N, Zaccaria A, Celso B, Tura S
Centro di Genetica e Citogenetica Oncologica, Istituto di Ematologia L. e A. Seràgnoli, Università di Bologna, Italy.
Haematologica. 1991 Jan-Feb;76(1):65-8.
We report a patient with M2 acute non-lymphocytic leukemia and a complex karyotype: 47,XY,t(5;7)(q34;q21), +8. After chemotherapy with Daunomycin and Arabinosyl Cytosine, a complete remission was reached, but two months later he relapsed and died because of sepsis. Only 5 other cases with translocations involving chromosomes 5 and 7 have been described, but with different breakpoints. Several genes related to cell proliferation and maturation have been identified on the long arms of chromosomes 5 and 7. The possible involvement of specific genes located at or very close to the breakpoints is hypothesized.
我们报告了一名患有M2型急性非淋巴细胞白血病且核型复杂的患者：47,XY,t(5;7)(q34;q21), +8。在用柔红霉素和阿糖胞苷进行化疗后，患者达到完全缓解，但两个月后复发并因败血症死亡。仅另有5例涉及5号和7号染色体易位的病例被描述，但断点不同。在5号和7号染色体长臂上已鉴定出几个与细胞增殖和成熟相关的基因。推测位于断点处或非常靠近断点的特定基因可能参与其中。
