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[腹主动脉择期手术中主动脉阻断对心功能的影响:冠状动脉血运重建的即刻效应]

[Effect of aortic clamping on heart function in elective operation of the abdominal aorta: immediate effects of coronary revascularization].

作者信息

Carrel T, Niederhäuser U, Laske A, Pasic M, Turina M

机构信息

Departement Chirurgie, Universitätsspital Zürich.

出版信息

Helv Chir Acta. 1993 Jun;59(5-6):849-54.

PMID:8376152
Abstract

Infrarenal aortic cross-clamping required during surgical treatment of abdominal aortic aneurysm is generally well tolerated but can be occasionally associated with severe cardiac and haemodynamic disturbances, particularly in patients suffering from coronary artery disease. We compared the haemodynamic changes and the ECG-records before and shortly after infrarenal aortic clamping in three groups of 20 patients (group I: without coronary artery disease, group II: with overt coronary disease without indication for prior myocardial revascularization, and group III: patients undergoing combined procedure: coronary artery bypass immediately prior to aortic repair, during the same anesthesia). There was no significant difference in demographical characteristics between the three groups. Aortic cross-clamping lead to an increase in systemic arterial pressure in all patients. Group I demonstrated a decrease in pulmonary artery pressure, pulmonary capillary wedge pressure and central venous pressure, whereas patients of group II demonstrated an increase of each value when the aorta was clamped. 11 patients of this group developed either arrhythmia and/or ischemia during aortic cross-clamping. Haemodynamic and cardiac effects of aortic clamping seen in patients who had received coronary bypass immediately prior to aortic repair (group III) were surprisingly similar to those of patients without coronary disease, probably owing to systematic application of 2 vasodilators. Tolerance to infrarenal aortic cross-clamping differs in patients with and without coronary artery disease. Development of myocardial ischemia may be predicted by an increase in wedge pressure after clamping. Afterload reduction was the best treatment of ischemia occurring when the aorta was clamped.

摘要

腹主动脉瘤手术治疗期间所需的肾下腹主动脉交叉钳夹通常耐受性良好,但偶尔可能与严重的心脏和血流动力学紊乱有关,特别是在患有冠状动脉疾病的患者中。我们比较了三组各20例患者在肾下腹主动脉钳夹前和钳夹后不久的血流动力学变化和心电图记录(第一组:无冠状动脉疾病;第二组:有明显冠状动脉疾病但无先前心肌血运重建指征;第三组:接受联合手术的患者:在主动脉修复前立即进行冠状动脉搭桥,在同一麻醉期间)。三组之间的人口统计学特征无显著差异。主动脉交叉钳夹导致所有患者的体循环动脉压升高。第一组肺动脉压、肺毛细血管楔压和中心静脉压降低,而第二组患者在主动脉钳夹时各值均升高。该组11例患者在主动脉交叉钳夹期间出现心律失常和/或缺血。在主动脉修复前立即接受冠状动脉搭桥的患者(第三组)中观察到的主动脉钳夹的血流动力学和心脏效应与无冠状动脉疾病的患者惊人地相似,这可能归因于系统应用了2种血管扩张剂。有和没有冠状动脉疾病的患者对肾下腹主动脉交叉钳夹的耐受性不同。钳夹后楔压升高可预测心肌缺血的发生。降低后负荷是主动脉钳夹时发生缺血的最佳治疗方法。

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