Scott R B, Tisdale S A, Cummings W B
Clin Pharmacol Ther. 1977 Feb;21(2):208-11. doi: 10.1002/cpt1977212208.
Methocarbamol, a compound related to mephenesin, has in vitro hemolytic potential. A study was performed to determine whether any hemolysis was detectable after intravenous injection. Methocarbamol and its vehicle (50% polyethylene glycol-300) was compared with vehicle alone and with normal saline controls in high- and low-dose regimens in normal volunteers. Significant increases in plasma hemoglobin were detected 30 min after intravenous injection of methocarbamol or its vehicle alone. Maximum initial plasma hemoglobin levels were approximately 10 mg/dl with vehicle alone, but only 4 mg/dl with the methocarbamol added. Serum haptoglobin levels fell after both high-dose methocarbamol and vehicle during the 3-day period of treatment. Hemolysis, though detectable, did not exceed levels found under physiologic circumstances such as exercise, and represents only a small fraction of the normal daily hemolysis of aged erythrocytes.
美索巴莫是一种与甲酚甘油醚相关的化合物，具有体外溶血潜力。进行了一项研究以确定静脉注射后是否可检测到溶血现象。在正常志愿者中，将美索巴莫及其溶媒（50%聚乙二醇-300）与单独的溶媒以及生理盐水对照进行高剂量和低剂量方案的比较。静脉注射美索巴莫或其单独溶媒后30分钟，检测到血浆血红蛋白显著增加。单独使用溶媒时，最大初始血浆血红蛋白水平约为10mg/dl，但添加美索巴莫后仅为4mg/dl。在3天的治疗期间，高剂量美索巴莫和溶媒后血清触珠蛋白水平均下降。溶血现象虽然可检测到，但未超过运动等生理情况下发现的水平，并且仅占衰老红细胞正常每日溶血的一小部分。
