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Some studies on peripheral actions of mephenesin, methocarbamol and diazepam.关于美芬新、甲氯芬酯和地西泮外周作用的一些研究。
Br J Pharmacol. 1968 Nov;34(3):579-90. doi: 10.1111/j.1476-5381.1968.tb08486.x.
2
Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials.美芬新、甲氯芬酯、氯氮䓬和地西泮：对脊髓反射和腹根电位的作用。
Br J Pharmacol. 1970 Jan;38(1):148-56. doi: 10.1111/j.1476-5381.1970.tb10343.x.
3
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Effects of new s-triazolobenzododiazepine (D-40TA) and other central muscle relaxants on spinal and supraspinal reflexes in cats.新型1,2,4-三唑并苯二氮䓬（D-40TA）及其他中枢性肌肉松弛剂对猫脊髓和脊髓上反射的影响。
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Methocarbamol blocks muscular Na 1.4 channels and decreases isometric force of mouse muscles.美索巴莫阻断肌肉钠离子通道 1.4 型并降低小鼠肌肉的等长收缩力。
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A peripheral component of centrally acting muscle relaxants: chlormezanone and mephenesin.中枢性肌肉松弛剂的外周成分：氯美扎酮和甲丙氨酯。
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Biphasic action of ethanol on contraction of skeletal muscle.乙醇对骨骼肌收缩的双相作用。
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Mode of action of Phoneutria nigriventer spider venom at the isolated phrenic nerve-diaphragm of the rat.
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1
Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.甲芬那酸与α-环糊精的主客体包合物在生物系统中的创新应用研究。
ACS Omega. 2024 Aug 15;9(34):36066-36075. doi: 10.1021/acsomega.3c08185. eCollection 2024 Aug 27.
2
Diazepam and neuromuscular blocking drugs.地西泮与神经肌肉阻滞药物。
Br Med J. 1971 Sep 11;3(5775):640. doi: 10.1136/bmj.3.5775.640-a.
3
Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials.美芬新、甲氯芬酯、氯氮䓬和地西泮：对脊髓反射和腹根电位的作用。
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4
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本文引用的文献

1
MUSCLE RELAXANTS.肌肉松弛剂
Practitioner. 1964 Jan;192:104-8.
2
A comparison between the effects of a tetanus and the effects of sympathomimetic amines on fast- and slow-contracting mammalian muscles.破伤风毒素与拟交感胺对哺乳动物快收缩和慢收缩肌肉作用的比较。
Br J Pharmacol Chemother. 1962 Dec;19(3):464-84. doi: 10.1111/j.1476-5381.1962.tb01451.x.
3
Effects of mephenesin on the repetitive discharge of spinal cord interneurones.美芬新对脊髓中间神经元重复放电的影响。
Arch Int Pharmacodyn Ther. 1961 Jun 1;132:222-36.
4
Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class.安定（商标名）——一种新型苯二氮䓬类精神治疗药物的药理及临床研究
Curr Ther Res Clin Exp. 1961 Sep;3:405-25.
5
A pharmacologic comparison of methocarbamol (AHR-85), the monocarbamate of 3-(o-methoxyphenoxy)-1,2-propanediol with chemically related interneuronal depressant drugs.3-(邻甲氧基苯氧基)-1,2-丙二醇的单氨基甲酸盐美索巴莫（AHR-85）与化学相关的中间神经元抑制药物的药理学比较。
J Pharmacol Exp Ther. 1958 Feb;122(2):239-46.
6
The correlation between animal testing procedures and clinical effectiveness of centrally acting muscle relaxants of the mephenesin type.美芬新类中枢性肌肉松弛剂的动物试验程序与临床疗效之间的相关性。
Ann N Y Acad Sci. 1956 Nov 16;64(4):705-29. doi: 10.1111/j.1749-6632.1956.tb36842.x.
7
The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain.迷走神经刺激对离体兔心脏的影响以及可卡因、六甲铵和哇巴因对其的影响。
J Physiol. 1956 Mar 28;131(3):678-89. doi: 10.1113/jphysiol.1956.sp005493.
8
Effects of 3-(o-toloxy)-propane-1,2-diol (mephenesin) and 3-(2-methyl-6-chlorophenoxy)-propane-1,2-diol (P105) on alpha-excitability of muscle.3-(邻甲苯氧基)-丙烷-1,2-二醇（美芬新）和3-(2-甲基-6-氯苯氧基)-丙烷-1,2-二醇（P105）对肌肉α兴奋性的影响。
Proc Soc Exp Biol Med. 1954 Mar;85(3):500-3. doi: 10.3181/00379727-85-20932.
9
Nerve block by mephenesin.美芬新神经阻滞
Anesthesiology. 1953 Jul;14(4):333-6. doi: 10.1097/00000542-195307000-00002.
10
A peripheral component of centrally acting muscle relaxants: chlormezanone and mephenesin.中枢性肌肉松弛剂的外周成分：氯美扎酮和甲丙氨酯。
J Pharmacol Exp Ther. 1967 Jan;155(1):145-51.

关于美芬新、甲氯芬酯和地西泮外周作用的一些研究。

Some studies on peripheral actions of mephenesin, methocarbamol and diazepam.

作者信息

Crankshaw D P, Raper C

出版信息

Br J Pharmacol. 1968 Nov;34(3):579-90. doi: 10.1111/j.1476-5381.1968.tb08486.x.

DOI:10.1111/j.1476-5381.1968.tb08486.x
PMID:5726787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703503/
Abstract
  1. Mephenesin, methocarbamol and diazepam abolished polysynaptic reflex contractions of the cat tibialis anterior muscle elicited by stimulation of the homolateral femoral nerve.2. Mephenesin and methocarbamol caused a prolongation of the mean refractory period of directly or indirectly stimulated skeletal muscle. These effects were due to a direct action on the muscle fibres. There was no effect on responses to single stimuli.3. The increase in refractory period produced by mephenesin was greater in indirectly than in directly stimulated rat diaphragms. Experiments using the isolated phrenic nerve suggest that this difference is due to the local anaesthetic action of mephenesin.4. In the indirectly stimulated cat tibialis anterior muscle high frequency stimulation resulted in a non-maintained tetanus in the presence of mephenesin and methocarbamol.5. Diazepam was without peripheral effects on the responses of skeletal muscle.6. The results with mephenesin and methocarbamol are discussed in relation to their mode of action in reducing muscle spasm.
摘要

  1. 美芬新、甲氨甲酰甲烷和地西泮可消除刺激同侧股神经引起的猫胫骨前肌多突触反射收缩。

  2. 美芬新和甲氨甲酰甲烷可使直接或间接刺激的骨骼肌平均不应期延长。这些作用是由于对肌纤维的直接作用。对单刺激反应无影响。

  3. 美芬新使间接刺激的大鼠膈肌不应期增加的幅度大于直接刺激的情况。使用离体膈神经的实验表明，这种差异是由于美芬新的局部麻醉作用。

  4. 在间接刺激的猫胫骨前肌中，高频刺激在有美芬新和甲氨甲酰甲烷存在时会导致非持续性强直收缩。

  5. 地西泮对骨骼肌反应无外周作用。

  6. 结合美芬新和甲氨甲酰甲烷在减轻肌肉痉挛方面的作用方式对结果进行了讨论。