来自库氏厚壳桂的黄酮酮和查耳酮衍生物。

Flavonone and chalcone derivatives from Cryptocarya kurzii.

作者信息

Fu X, Sévenet T, Remy F, Païs M, Hamid A, Hadi A, Zeng L M

机构信息

Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur- Yvette, France.

出版信息

J Nat Prod. 1993 Jul;56(7):1153-63. doi: 10.1021/np50097a021.

DOI:10.1021/np50097a021

PMID:8377019

Abstract

Four complex flavanones, kurziflavolactones A [2], B [3], C [4], and D [5] and a complex chalcone 6 with an unprecedented carbon side chain on the flavanone or chalcone A ring have been isolated from a Malaysian plant, Cryptocarya kurzii (Lauraceae). Their structures were determined by extensive spectroscopic analysis, especially 2D nmr experiments. Compounds 3 and 6 showed slight cytotoxicity against KB cells, with IC50 values of 4 and 15 micrograms/ml, respectively. A biosynthetic pathway for the formation of these compounds is suggested.

摘要

从马来西亚植物Cryptocarya kurzii（樟科）中分离出了四种复杂的黄烷酮，即kurziflavolactones A [2]、B [3]、C [4]和D [5]，以及一种在黄烷酮或查耳酮A环上带有前所未有的碳侧链的复杂查耳酮6。它们的结构通过广泛的光谱分析确定，尤其是二维核磁共振实验。化合物3和6对KB细胞显示出轻微的细胞毒性，IC50值分别为4和15微克/毫升。本文提出了这些化合物形成的生物合成途径。