Perler B A, Kolk C A, Manson P M, Williams G M
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287-4685.
J Vasc Surg. 1993 Sep;18(3):358-64; discussion 364-5.
The conventional management of prosthetic graft infection (PGI), including graft excision and extraanatomic revascularization, continues to be associated with substantial morbidity. Rotational muscle flap (RMF) closure of the infected wound, with preservation of the graft, is an alternative, albeit controversial, approach.
Over the last 7 years, 22 RMF procedures have been performed to close 19 wounds in 18 patients, ranging in age from 39 to 79 (mean 63.7) years, with PGI. Twenty-one grafts constructed of Dacron (13) or polytetrafluoroethylene (8) were covered in the groin (16), neck (2), or chest (1). The clinical presentations included abscess or purulent drainage in 14 grafts, hemorrhage in three, and infected false aneurysm in two wounds; positive bacterial culture results were obtained in each case.
There was one (5.6%) operative death. Healing was achieved in the 18 wounds of the 17 operative survivors. No patients have been lost to follow-up. Three (17.6%) of these 17 patients had recurrent infection, including one patient who underwent a secondary RMF procedure with graft salvage, one who underwent excision of an occluded graft, and one who underwent excision and extraanatomic bypass and died. Four other patients died 1 to 6 (mean 3) months after RMF closure with healed wounds. Eleven (92%) of the 12 survivors have healed wounds and intact grafts with follow-up ranging from 8 to 83 (mean 39) months. For the entire series 15 (88%) of these 17 patients had healed wounds and intact grafts, with a mean follow-up of 30 months.
These results suggest that RMF procedures are well tolerated and can achieve acceptable long-term graft salvage in selected patients with PGI.
人工血管移植物感染(PGI)的传统治疗方法,包括移植物切除和解剖外血管重建,仍然伴随着较高的发病率。采用旋转肌皮瓣(RMF)闭合感染伤口并保留移植物,是一种替代方法,尽管存在争议。
在过去7年中,对18例年龄在39至79岁(平均63.7岁)的PGI患者进行了22次RMF手术,以闭合19处伤口。21个由涤纶(13个)或聚四氟乙烯(8个)制成的移植物覆盖于腹股沟(16处)、颈部(2处)或胸部(1处)。临床表现包括14个移植物出现脓肿或脓性引流、3个移植物出血以及2处伤口出现感染性假性动脉瘤;所有病例的细菌培养结果均为阳性。
有1例(5.6%)手术死亡。1名手术幸存者的18处伤口均愈合。无患者失访。这17例患者中有3例(17.6%)发生复发性感染,其中1例患者接受了二次RMF手术并成功保留移植物,1例患者接受了闭塞移植物切除术,1例患者接受了切除和解剖外旁路手术,术后死亡。另外4例患者在RMF闭合伤口愈合后1至6个月(平均3个月)死亡。12名幸存者中有11名(92%)伤口愈合且移植物完好,随访时间为8至83个月(平均39个月)。在整个系列中,这17例患者中有15例(88%)伤口愈合且移植物完好,平均随访时间为30个月。
这些结果表明,RMF手术耐受性良好,对于部分PGI患者能够实现可接受的长期移植物保留。