Yamashina H
First Department of Internal Medicine, Toho University School of Medicine, Tokyo.
Kaku Igaku. 1993 Jul;30(7):769-78.
111In-labeled low-density lipoprotein (LDL) was administered to Watanabe heritable hyperlipidemic rabbits (WHHL group) and control rabbits (control group) to evaluate its biodistribution and scintigraphic images by gamma-camera and radioactivity of each organ. With external imaging, the heart, liver, kidney, bone and spleen of each rabbit were observed. By setting the region of interest, the liver/heart ratio of the WHHL group was significantly lower than that of the control group (p < 0.05), the plasma half life of LDL was longer and radioactivity in blood, heart and aorta was higher in the WHHL group. Each aorta was autoradiographed and significant accumulation of 111In-labeled-LDL was recognized in the aortic arch, bifurcation of intercostal and celiac artery in the WHHL group. By the use of labeled LDL with the combination of gamma-camera, it is capable of detecting the regulation of lipoprotein metabolism and imaging atherosclerotic lesions externally.
将111铟标记的低密度脂蛋白（LDL）注射给渡边遗传性高脂血症兔（WHHL组）和对照兔（对照组），以通过γ相机评估其生物分布和闪烁图像以及各器官的放射性。通过外部成像，观察每只兔子的心脏、肝脏、肾脏、骨骼和脾脏。通过设置感兴趣区域，WHHL组的肝脏/心脏比值显著低于对照组（p<0.05），WHHL组的LDL血浆半衰期更长，血液、心脏和主动脉中的放射性更高。对每条主动脉进行放射自显影，在WHHL组的主动脉弓、肋间动脉和腹腔动脉分支中发现111铟标记的LDL有明显积聚。通过使用标记的LDL结合γ相机，能够从外部检测脂蛋白代谢的调节并对动脉粥样硬化病变进行成像。
