Kohno H, Mori M, Katayama T
Pharmaceutical Division, National Tokyo Chest Hospital, Japan.
Kekkaku. 1993 Aug;68(8):511-6.
To investigate genetic polymorphism of N-acetylation in Japanese population we measured isoniazid (INH) and acetylisoniazid (AcINH) in the urine of 340 unrelated Japanese subjects. For the detection of polymorphism, we used probit analysis, logit analysis, and arcsine transformation of the logarithm of molar acetylation ratio (log (INH/AcINH)). The observed antimodes were -0.85 and -0.325 for the probit, 4.899 and 7.154 for the logit, 43.85 and 71.57 for the arcsine analysis plot. Probit and arcsine analysis were sensitive for the separation of intermediate from slow acetylators, while logit analysis was sensitive for the separation of rapid from intermediate acetylators. Clinically it is important to know to which genetic group the patient belongs because we may have to increase the dosage for the rapid acetylators to achieve the desired therapeutic effect, while we may have to reduce the dosage for slow acetylators in whom the incidence of side effect is high.
为研究日本人群中N - 乙酰化的基因多态性，我们检测了340名无亲缘关系的日本受试者尿液中的异烟肼（INH）和乙酰异烟肼（AcINH）。为检测多态性，我们使用了概率分析、对数分析以及摩尔乙酰化率对数的反正弦转换（log(INH/AcINH)）。概率分析的观察到的反众数为 -0.85和 -0.325，对数分析为4.899和7.154，反正弦分析图为43.85和71.57。概率分析和反正弦分析对于区分中间型与慢乙酰化者很敏感，而对数分析对于区分快乙酰化者与中间型乙酰化者很敏感。临床上了解患者属于哪个基因群体很重要，因为对于快乙酰化者我们可能不得不增加剂量以达到预期的治疗效果，而对于慢乙酰化者我们可能不得不减少剂量，因为他们副作用的发生率较高。
