Itoh Y, Yamada M, Hayakawa M, Otomo E, Miyatake T
Department of Internal Medicine, Yokufukai Geriatric Hospital, Tokyo, Japan.
Neurosci Lett. 1993 Jun 11;155(2):144-7. doi: 10.1016/0304-3940(93)90693-f.
In order to clarify the significance of subpial beta/A4 peptide deposits (SP beta PD), we examined the brains of 160 consecutive autopsied cases (average age 84.4 +/- 7.7 years) with or without dementia of the Alzheimer type (DAT) pathologically and immunohistochemically. SP beta PD and amyloid angiopathy (AA) showed a significant positive correlation in their severities, both in the DAT and non-DAT groups. AA was present in most cases with SP beta PD, but was absent in all cases without SP beta PD. Our results suggest that SP beta PD and AA would be the related lesions, and that SP beta PD would be formed previous to AA.
为了阐明软膜下β/A4肽沉积（SPβPD）的意义，我们对160例连续尸检病例（平均年龄84.4±7.7岁）的大脑进行了病理和免疫组织化学检查，这些病例有无阿尔茨海默型痴呆（DAT）。在DAT组和非DAT组中，SPβPD和淀粉样血管病（AA）的严重程度均呈显著正相关。大多数有SPβPD的病例存在AA，但所有无SPβPD的病例均无AA。我们的结果表明，SPβPD和AA可能是相关病变，且SPβPD可能在AA之前形成。
