Behrouz N, Defossez A, Delacourte A, Mazzuca M
National Institute of Health and Medical Research (INSERM 156), Lille, France.
J Gerontol. 1991 Nov;46(6):B209-12. doi: 10.1093/geronj/46.6.b209.
We performed an immunocytochemical study of cerebral cortex from cases of Alzheimer's disease and from aged nondemented controls, using periodic acid pretreatment and polyclonal beta-protein antibodies. In addition to senile plaques (SP) and amyloid angiopathy (AA), the beta-protein antibodies detected band-like deposits present throughout the cortical layers. Moreover, large plaque-like infiltrations with diffuse and amorphous characteristics were observed in the cortical gray and white matter, and these deposits were often associated with capillaries. Our results suggest that an abundance of these lesions, which were detected only with this immunostaining procedure in Alzheimer cortex, may be characteristic of Alzheimer's disease.
我们使用高碘酸预处理和多克隆β-蛋白抗体，对阿尔茨海默病患者及老年非痴呆对照者的大脑皮质进行了免疫细胞化学研究。除了老年斑（SP）和淀粉样血管病（AA）外，β-蛋白抗体还检测到贯穿皮质各层的带状沉积物。此外，在皮质灰质和白质中观察到具有弥漫性和无定形特征的大斑块样浸润，这些沉积物常与毛细血管相关。我们的结果表明，这些仅在阿尔茨海默病皮质中通过这种免疫染色程序检测到的大量病变，可能是阿尔茨海默病的特征。
