Mieda C, Hirota S, Soejima T, Oshitani T, Motohara T, Koizumi T, Yoshida S, Hasegawa K, Ohtsu F, Takeuchi K
Department of Radiology, Hyogo Medical Center for Adults.
Nihon Igaku Hoshasen Gakkai Zasshi. 1993 Jul 25;53(7):827-34.
Thirty-four patients with carcinoma of the vagina were treated by radiotherapy at the Hyogo Medical Center for Adults between April 1965 and May 1990. All patients were treated with a combination of external and intracavitary or intestinal irradiation. Twenty-three patients had squamous cell carcinoma, five had adenocarcinoma and two had malignant melanoma. The five-year survival of patients with squamous cell carcinoma was 70% in Stage I (10 patients), 40% in Stage II (seven patients), 50% in Stage III (three patients) and 0% in Stage IV (three patients). Local control was achieved in 72.7% of the patients with squamous cell carcinoma and 60% of those with adenocarcinoma. However, neither of the malignant melanomas was controlled. Five patients had severe complications that required surgical treatment: severe proctitis and small-bowel perforation, ileus, rectal stenosis, vesicovaginal fistula and small-bowel perforation. Local and pelvic failure was noted in three patients. Patients with previous hysterectomy were more likely to develop serious treatment-related complications.
1965年4月至1990年5月期间，34例阴道癌患者在兵库成人医学中心接受了放射治疗。所有患者均接受了体外照射与腔内或肠内照射相结合的治疗。23例为鳞状细胞癌，5例为腺癌，2例为恶性黑色素瘤。鳞状细胞癌患者的五年生存率在I期（10例）为70%，II期（7例）为40%，III期（3例）为50%，IV期（3例）为0%。鳞状细胞癌患者的局部控制率为72.7%，腺癌患者为60%。然而，两例恶性黑色素瘤均未得到控制。5例患者出现严重并发症，需要手术治疗：严重直肠炎伴小肠穿孔、肠梗阻、直肠狭窄、膀胱阴道瘘和小肠穿孔。3例患者出现局部和盆腔失败。既往接受过子宫切除术的患者更易发生严重的治疗相关并发症。
