脂蛋白代谢与动脉粥样硬化的转基因小鼠模型。
Transgenic mouse models of lipoprotein metabolism and atherosclerosis.
作者信息
Breslow J L
机构信息
Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021-6399.
出版信息
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8314-8. doi: 10.1073/pnas.90.18.8314.
Abstract
Lipoprotein transport genes have either been added to the germ line of mice by transgenic techniques or knocked out by homologous recombination in embryonic stem cells. The resultant over- or underexpression of these genes has resulted in new insights about how these genes function in the body and their role in lipoprotein metabolism. Either singly or in combination, these genetic modifications can be used to engineer the mouse to make it a better model for human lipoprotein disorders and atherosclerosis.
摘要
脂蛋白转运基因要么通过转基因技术被添加到小鼠的生殖系中，要么通过胚胎干细胞中的同源重组被敲除。这些基因的过表达或低表达带来了关于这些基因在体内如何发挥作用及其在脂蛋白代谢中作用的新见解。这些基因修饰单独或组合使用，可用于改造小鼠，使其成为人类脂蛋白紊乱和动脉粥样硬化的更好模型。
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