Martínez J A, Elorriaga M, Marquínez M, Larralde J
Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain.
Rev Esp Fisiol. 1993 Mar;49(1):37-41.
Oral administration of bone extracts obtained from bovine demineralized bone matrix to rats has a direct effect on bone metabolism, affecting bone proportions and some markers of bone formation such as bone malate dehydrogenase, serum alkaline phosphatase and serum osteocalcin. Furthermore collagen deposition, bone protein synthesis and nucleic acids content were significantly increased by the treatment.
给大鼠口服从牛脱矿骨基质中提取的骨提取物对骨代谢有直接影响，会影响骨比例以及一些骨形成标志物，如骨苹果酸脱氢酶、血清碱性磷酸酶和血清骨钙素。此外，该处理显著增加了胶原蛋白沉积、骨蛋白合成和核酸含量。
