In vivo inhibition of thyroid secretion by indomethacin.

Indomethacin (Ind) was administered to adult female rats to reduce endogenous prostaglandin (PG) synthesis in order to investigate the role of PGs in thyroid hormone secretin. This treatment markedly reduced thyroidal PGF levels (667.7 vs. 1822.1 pg/my, P less than .001). Although the plasma TSH concentrations were normal in the Ind-treated group (41.14 vs. 40.01 mug/100 ml), dramatic decreases were observed in plasma T3 (24.5 ca. 6.7 nf/100 ml, P less than .001) and T4 (5.6 vs. 0.7 mug/100 ml, P less than .001) levels...