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In vivo inhibition of thyroid secretion by indomethacin.

作者信息

Thompson M E, Orczyk G P, Hedge G A

出版信息

Endocrinology. 1977 Apr;100(4):1060-7. doi: 10.1210/endo-100-4-1060.

DOI:10.1210/endo-100-4-1060
PMID:837875
Abstract

Indomethacin (Ind) was administered to adult female rats to reduce endogenous prostaglandin (PG) synthesis in order to investigate the role of PGs in thyroid hormone secretin. This treatment markedly reduced thyroidal PGF levels (667.7 vs. 1822.1 pg/my, P less than .001). Although the plasma TSH concentrations were normal in the Ind-treated group (41.14 vs. 40.01 mug/100 ml), dramatic decreases were observed in plasma T3 (24.5 ca. 6.7 nf/100 ml, P less than .001) and T4 (5.6 vs. 0.7 mug/100 ml, P less than .001) levels...

摘要

相似文献

1
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引用本文的文献

1
Inhibition of TSH-stimulated thyroid hormone release and potentiation of TRH-stimulated TSH release by indomethacin in perifusion systems of rat thyroids and pituitaries.在大鼠甲状腺和垂体的灌流系统中，吲哚美辛对促甲状腺激素（TSH）刺激的甲状腺激素释放具有抑制作用，对促甲状腺激素释放激素（TRH）刺激的TSH释放具有增强作用。
Experientia. 1984 Dec 15;40(12):1429-31. doi: 10.1007/BF01951928.
2
Colloid droplet accumulation precedes the enhancement of 6-keto-PGF 1 alpha release from the thyrotropin-stimulated thyroid gland.
J Endocrinol Invest. 1985 Aug;8(4):293-5. doi: 10.1007/BF03348499.