Mashita K, Tajima K, Kawamura S, Tarui S
Experientia. 1984 Dec 15;40(12):1429-31. doi: 10.1007/BF01951928.
Using indomethacin (Ind), a prostaglandin synthesis inhibitor, in vivo experiments in rats and in vitro experiments with perifusion systems of rat thyroids and pituitaries were conducted. After 35 days of intragastric infusion of Ind, serum TSH levels were markedly increased, the thyroid was swollen and, as a consequence, T3 and T4 levels were normal. The T3 release from perifused rat thyroids under continuous stimulation with 10 mU/ml TSH was inhibited significantly (p less than 0.01) by 1.0 X 10(-6) M Ind. On the other hand, the TSH release from perifused rat pituitaries under TRH stimulation was enhanced conspicuously by Ind. It was concluded that Ind decelerated thyroid hormone release from the thyroid and accelerated TSH release from the pituitary in perifusion systems.
使用前列腺素合成抑制剂吲哚美辛（Ind），对大鼠进行了体内实验，并对大鼠甲状腺和垂体的灌流系统进行了体外实验。在胃内输注Ind 35天后，血清促甲状腺激素（TSH）水平显著升高，甲状腺肿大，结果三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平正常。在10 mU/ml TSH持续刺激下，1.0×10⁻⁶ M Ind显著抑制了灌流大鼠甲状腺的T3释放（p<0.01）。另一方面，Ind显著增强了促甲状腺激素释放激素（TRH）刺激下灌流大鼠垂体的TSH释放。得出的结论是，在灌流系统中，Ind减缓了甲状腺的甲状腺激素释放，并加速了垂体的TSH释放。
