Grollman A P, Moriya M
Department of Pharmacological Sciences, State University of New York, Stony Brook 11794-8651.
Trends Genet. 1993 Jul;9(7):246-9. doi: 10.1016/0168-9525(93)90089-z.
The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.
细胞中活性氧的存在确保了氧化损伤碱基8-氧代鸟嘌呤会在所有生物体的DNA中高频产生。DNA损伤威胁基因组完整性：已经进化出了一些酶来保护原核生物和真核生物免受这种普遍存在的损伤的诱变作用。
